Registration

Welcome and opening of the meeting

Lecture 1

Chair: Pier Lorenzo Puri

Alessandra Sacco (Sanford Burnham, La Jolla, CA, USA)
Dynamics of muscle stem cells during tissue growth and regeneration

Session 1: Genetic and epigenetic alterations in muscle dystrophies and myopathies

Chairs: Marianna Cosentino and Samuele Metti

Irene Casola
Circulating microRNAs in ALS disease

Michela Lisi
Epigenetic regulation of a splicing factor involved in Duchenne Muscular Dystrophy

Alessandra Renzini
New emerging role for HDAC4 on sarcolemma stability in DMD

Coffee break

Welcome from Authorities

Session 2: Satellite cells and muscle regeneration in healthy muscle and in diseases

Chairs: Ester Di Filippo and Alessandra Renzini

Marlies Corvelyn
Muscle stem cells from developing children with cerebral palsy: a pilot study

Simona Feno
Physiopathological characterization of the role of MCUb in skeletal muscle regeneration

Biliana Lozanoska-Ochser
Splenic Ly6C^hi monocytes are critical players in dystrophic muscle injury and repair

Graziella Messina
Approaches to delay the progression of Muscular Dystrophy

Simone Vumbaca
Dissecting the secretome during muscle regeneration: role and kinetics of cytokines and extra-cellular vesicles

Aperitivo Umbro and (only for participants registered to the High Training formula) Rountable Discussions

Lecture 2

Chair: Elena Barbieri

Bente Klarlund Pedersen (University of Copenhagen, Copenhagen, Denmark)
Muscle as an endocrine organ

Session 3: Biophysics and E-C coupling in the pathophysiology of neuromuscular diseases

Chairs: Giosuè Annibalini and Biliana Lozanoska-Ochser

Ersilia Fornetti
Organ-on-a-chip modelling of the human neuromuscular junction in both physiological and pathological conditions

Caterina Marchioretti
Polyglutamine-expanded androgen receptor alters excitation-contraction coupling machinery and calcium dynamics

Antonio Michelucci
Transverse Tubule Remodeling Enhances Orai1-dependent Ca²⁺ Entry in Skeletal Muscle

Coffee break

Session 4: Signaling in muscle growth, homeostasis and diseases

Chairs: Giorgia Catarinella and Carles Sanchez Riera

Ana Georgia Dumitras
The regulation of protein synthesis and muscle plasticity

Matteo Giovarelli
Drp1 promotes mitochondrial transport and repositioning in muscle by enhancing kinesin-1 activation

Roberto Mantovani
The NF-Y regulome in mouse fetal myoblasts reveals a role of SREBP in differentiation

Giorgia Pallafacchina
Unveiling novel and specific functions of protein kinase CK2 subunits in skeletal muscle differentiation and fusogenic activity

Alessio Reggio
Adipogenesis of skeletal muscle Fibro/Adipogenic Progenitors is controlled by the Wnt5a/GSK3/b-catenin axis

Valentina Taglietti
Evo-Devo approach to study Pax3/7 functions

Lunch

Poster discussion

Coffee break

Bus departure: guided tour of Montefalco and Dinner at Cantina Lungarotti

Lecture 3

Chair: Davide Gabellini

Bénédicte Chazaud (Institut NeuroMyoGène, Lyon, France)
Roles of macrophages in normal skeletal muscle regeneration versus muscle disease

Session 5: Metabolic alterations and muscle diseases

Chairs: Valentina Taglietti and Marlies Corvelyn

Gaia Butera
Mitochondrial adaptation in parvalbumin knockout muscle fibers

Gaia Gherardi
Regulation of oxidative metabolism and substrate preferences in aged skeletal muscle by mitochondrial calcium uptake

Marco Rosina
Metabolic reprogramming of Fibro/Adipogenic Progenitors facilitates muscle regeneration

Davide Steffan
Identification of a novel TFEB and exercise dependent gene

Coffee break

Session 6: Muscle fibrosis, sarcopenia and cachexia

Chairs: Sara Chiappalupi and Giacomo Valli

Maraiza Alves Teixeira
Direct effects of vitamin D₃ (cholecalciferol) on skeletal muscle

Sestina Falcone
rGDF5, an unexpected treatment against age-related muscle mass loss

Nicoletta Filigheddu
The role of vitamin D binding protein in the onset of cancer cachexia - beyond vitamin D transport

Michele Mannelli
A metabolic shift drives cancer cachexia in myotubes

Susanna Molinari
PIN1: a putative molecular target to protect skeletal muscle against age-related muscle loss

Federica Pierucci
Involvement of CerK in skeletal muscle atrophy

Aleksandra Vukasinovic
Receptor for advanced glycation end-products (RAGE) as a biomarker of muscle wasting in cancer conditions

Lunch

Poster discussion

IIM young committee invited lecture

Chair: Gaia Gherardi

Olivier Pourquié (Harvard Stem Cell Institute, Boston, MA, USA)
In vitro modeling of human muscle development and disease

Coffee break

Session 7: Therapeutic approaches for muscle diseases

Chairs: Giulia Terribile and Emanuele Mocciaro

Marianna Cosentino
A novel 3D culture system as an in vitro model for muscle disease

Sara Chiappalupi
Use of Sertoli cells to treat DMD patients is supported by their immunomodulatory rather than immunosuppressive effect

Gloria Antonini
The voice of patients affected by Duchenne and Becker Muscular Dystrophies

Samuele Metti
Pterostilbene induces autophagic flux in Collagen VI-deficient muscle

Paulina Melania Roux-Biejat
Inhibition of Acid Sphingomyelinase as Novel Alternative Therapy for Duchenne Muscular Dystrophy

Stefano Testa
A novel wet-spinning system for 3D bioprinting of an artificial skeletal muscle tissue

Libero Vitiello
Hitting DMD With a One-Two Punch: a Novel MAOB/VAP1 Inhibitor Greatly Improves the Pathological Phenotype in mdx Mice

IIM General meeting

Social Dinner - Awards and prizes

Dance party

bus to Palazzo Bernabei

Olivier Pourquie (Harvard Stem Cell Institute, Boston, USA)
Skeletal muscle development in vertebrates

Discussion

Alessandra Sacco (Sanford Burnham La Jolla, CA, USA))
Exercise-induced injury muscle-stem cell responses

Discussion

Benedicte Chazaud (Institut NeuroMyoGène, Lyon, France)
Exercise-induced injury non-muscle cell responses

Discussion

Bente Klarlund Pedersen (University of Copenhagen, Denmark)
Hormonal responses to exercise

Discussion

Marco Narici (University of Padua, Italy)
Neuromuscular adaptation to exercise and inactivity

Discussion

Lunch

bus to hotel Il Cenacolo